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The Interaction of Dynamic Cerebral Autoregulation and Neurovascular Coupling in Cognitive Impairment

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posted on 2022-01-18, 15:36 authored by Lucy C Beishon, Kannakorn Intharakham, Victoria J Haunton, Thompson G Robinson, Ronney B Panerai
Background: Dynamic cerebral autoregulation (dCA) remains intact in both ageing and dementia, but studies of neurovascular coupling (NVC) have produced mixed findings.

Objective: We investigated the effects of task-activation on dCA in healthy older adults (HOA), and patients with mild cognitive impairment (MCI) and Alzheimer’s Disease (AD).

Methods: Resting and task-activated data from thirty HOA, twenty-two MCI, and thirty-four AD were extracted from a database. The autoregulation index (ARI) was determined at rest and during five cognitive tasks from transfer function analysis. NVC responses were present where group-specific thresholds of cross-correlation peak function and variance ratio were exceeded. Cumulative response rate (CRR) was the total number of positive responses across five tasks and two hemispheres.

Results: ARI differed between groups in dominant (p=0.012) and non-dominant (p=0.042) hemispheres at rest but not during task-activation (p=0.33). ARI decreased during language and memory tasks in HOA (p=0.002) but not in MCI or AD (p=0.40). There was a significant positive correlation between baseline ARI and CRR in all groups (r=0.26, p=0.018), but not within sub-groups.

Conclusion: dCA efficiency was reduced in task-activation in healthy but not cognitively impaired participants. These results indicate differences in neurovascular processing in healthy older adults relative to cognitively impaired individuals.

Funding

LB is a Dunhill clinical research training fellow (RTF1806\27). KI is supported by a PhD scholarship of the Ministry of Higher Education, Science, Research and Innovation of the Royal Thai Government. TGR is a National Institute for Health Research (NIHR) Senior Investigator.

History

Citation

Current Alzheimer Research, Volume 18 , Issue 14 , 2021. https://doi.org/10.2174/1567205019666211227102936

Author affiliation

Department of Cardiovascular Sciences, University of Leicester

Version

  • AM (Accepted Manuscript)

Published in

Current Alzheimer Research

Volume

18

Issue

14

Pagination

1067 - 1076

Publisher

Bentham Science Publishers Ltd.

issn

1567-2050

Copyright date

2021

Available date

2022-12-27

Language

en

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