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The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease.pdf (2.02 MB)

The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease

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posted on 2023-05-25, 08:59 authored by S Mendes, DV Leal, LA Baker, A Ferreira, AC Smith, JL Viana
Chronic Kidney Disease (CKD) is a global health burden with high mortality and health costs. CKD patients exhibit lower cardiorespiratory and muscular fitness, strongly associated with morbidity/mortality, which is exacerbated when they reach the need for renal replacement therapies (RRT). Muscle wasting in CKD has been associated with an inflammatory/oxidative status affecting the resident cells’ microenvironment, decreasing repair capacity and leading to atrophy. Exercise may help counteracting such effects; however, the molecular mechanisms remain uncertain. Thus, trying to pinpoint and understand these mechanisms is of particular interest. This review will start with a general background about myogenesis, followed by an overview of the impact of redox imbalance as a mechanism of muscle wasting in CKD, with focus on the modulatory effect of exercise on the skeletal muscle microenvironment.

Funding

Portuguese Foundation of Science and Technology (FCT) doctoral grant (SFRH/BD/07740/2020

The Research Center in Sports Sciences, Health Sciences and Human Development is funded by FCT (UID/04045/2020)

History

Author affiliation

Department of Health Sciences, University of Leicester

Version

  • VoR (Version of Record)

Published in

International Journal of Molecular Sciences

Volume

24

Issue

7

Pagination

6017

Publisher

MDPI

issn

1661-6596

eissn

1422-0067

Copyright date

2023

Available date

2023-05-25

Spatial coverage

Switzerland

Language

eng

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