University of Leicester
Browse

File(s) under permanent embargo

Reason: 12 month embargo on AAM - requested from Author

The effect of acute and chronic exercise on hepatic lipid composition

journal contribution
posted on 2023-10-13, 08:21 authored by SA Willis, S Malaikah, S Parry, S Bawden, G Ennequin, JA Sargeant, T Yates, DR Webb, MJ Davies, DJ Stensel, GP Aithal, JA King

Exercise is recommended for those with, or at risk of nonalcoholic fatty liver disease (NAFLD), owing to beneficial effects on hepatic steatosis and cardiometabolic risk. Whilst exercise training reduces total intrahepatic lipid in people with NAFLD, accumulating evidence indicates that exercise may also modulate hepatic lipid composition. This metabolic influence is important as the profile of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) dramatically affect the metabolic consequences of hepatic lipid accumulation; with SFA being especially lipotoxic. Relatedly, obesity and NAFLD are associated with hepatic PUFA depletion and elevated SFA. This review summarizes the acute (single bout) and chronic (exercise training) effects of exercise on hepatic lipid composition in rodents (acute studies: n = 3, chronic studies: n = 13) and humans (acute studies: n = 1, chronic studies: n = 3). An increased proportion of hepatic PUFA after acute and chronic exercise is the most consistent finding of this review. Mechanistically, this may relate to an enhanced uptake of adipose-derived PUFA (reflecting habitual diet), particularly in rodents. A relative decrease in the proportion of hepatic MUFA after chronic exercise is also documented repeatedly, particularly in rodent models with elevated hepatic MUFA. This outcome is related to decreased hepatic stearoyl-CoA desaturase-1 activity in some studies. Findings regarding hepatic SFA are less consistent and limited by the absence of metabolic challenge in rodent models. These findings require confirmation in well-controlled interventions in people with NAFLD. These studies will be facilitated by recently validated magnetic resonance spectroscopy techniques, able to precisely quantify hepatic lipid composition in vivo.

Funding

NIHR Leicester Biomedical Research Centre

NIHR Nottingham Biomedical Research Centre

History

Author affiliation

NIHR Biomedical Research Unit, University of Leicester

Version

  • VoR (Version of Record)

Published in

Scandinavian Journal of Medicine and Science in Sports

Volume

33

Issue

5

Pagination

550 - 568

Publisher

Wiley

issn

0905-7188

eissn

1600-0838

Copyright date

2023

Spatial coverage

Denmark

Language

eng

Usage metrics

    University of Leicester Publications

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC