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The effect of head positioning on cerebral hemodynamics: Experiences in mild ischemic stroke.

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posted on 2020-11-20, 15:54 authored by Man Y Lam, Victoria J Haunton, Mintu Nath, Ronney B Panerai, Thompson G Robinson
BACKGROUND AND PURPOSE: It is generally agreed that optimal head positioning is an important consideration in acute stroke management regime. However, there is limited literature investigating the effect of head positioning changes on cerebrovascular physiology in acute ischemic stroke (AIS). We aim to assess cerebral autoregulation (CA) and associated hemodynamic responses during gradual head positioning (GHP) changes, between AIS and controls. METHODS: Cerebral blood flow velocity (CBFV, transcranial Doppler), blood pressure (BP, Finometer) and end-tidal CO2 (capnography) were recorded between lying flat (0°) and sitting up (30°) head position, in 16 controls (8 women, mean age 57 ± 16 yrs) and 15 AIS patients (7 women, 69 ± 8 yrs). AIS patients carried out three visits at 13.3 ± 6.9 h, 4.8 ± 3.2 days and 93.9 ± 11.5 days from symptom onset, respectively. RESULTS: AIS patients were significantly hypertensive (p = 0.005), hypocapnic (p < 0.001), and had lower CBFV (p = 0.02) compared to controls, in both head positions. When comparing 5-min FLAT to SIT head position, reductions in BP (both AIS and controls, p < 0.001) and CBFV (controls only: dominant hemisphere p = 0.001 and non-dominant hemisphere p = 0.05) were demonstrated. Of note, a reduction in autoregulation index was observed in AIS, after 5-min SIT head positioning, at all 3 visits (p = 0.018). CONCLUSION: Key hemodynamic changes were demonstrated when the head position changes from 5-min FLAT to SIT head position (GHP) in mildly affected stroke patients. Importantly, these were associated with non-significant changes in CBFV but reduced measures of CA following AIS, which may be relevant in determining the optimal head position and the ideal timing of mobilisation. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique Identifier: NCT02932540.

History

Citation

Journal of the Neurological Sciences Volume 419, 15 December 2020, 117201

Author affiliation

Department of Cardiovascular Sciences

Version

  • AM (Accepted Manuscript)

Published in

Journal of the Neurological Sciences

Volume

419

Pagination

117201

Publisher

Elsevier BV

issn

0022-510X

eissn

1878-5883

Acceptance date

2020-10-19

Copyright date

2020

Available date

2021-10-21

Spatial coverage

Netherlands

Language

eng

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