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The impact of eliminating age inequalities in stage at diagnosis on breast cancer survival for older women..pdf (255 kB)

The impact of eliminating age inequalities in stage at diagnosis on breast cancer survival for older women

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journal contribution
posted on 2016-02-22, 09:51 authored by Mark J. Rutherford, G. A. Abel, D. C. Greenberg, Paul C. Lambert, G. Lyratzopoulos
BACKGROUND: Older women with breast cancer have poorer relative survival outcomes, but whether achieving earlier stage at diagnosis would translate to substantial reductions in mortality is uncertain. METHODS: We analysed data on East of England women with breast cancer (2006-2010) aged 70+ years. We estimated survival for different stage-deprivation-age group strata using both the observed and a hypothetical stage distribution (assuming that all women aged 75+ years acquired the stage distribution of those aged 70-74 years). We subsequently estimated deaths that could be postponed beyond 5 years from diagnosis if women aged 75+ years had the hypothetical stage distribution. We projected findings to the English population using appropriate age and socioeconomic group weights. RESULTS: For a typically sized annual cohort in the East of England, 27 deaths in women with breast cancer aged 75+ years can be postponed within 5 years from diagnosis if their stage distribution matched that of the women aged 70-74 years (4.8% of all 566 deaths within 5 years post diagnosis in this population). Under assumptions, we estimate that the respective number for England would be 280 deaths (5.0% of all deaths within 5 years post diagnosis in this population). CONCLUSIONS: The findings support ongoing development of targeted campaigns aimed at encouraging prompt presentation in older women.

History

Citation

British Journal of Cancer , 2015, 112 Suppl 1, pp. S124-S128

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

Version

  • VoR (Version of Record)

Published in

British Journal of Cancer

Publisher

Cancer Research UK, Nature Publishing Group

issn

0007-0920

eissn

1532-1827

Copyright date

2015

Available date

2016-02-22

Publisher version

http://www.nature.com/bjc/journal/v112/n1s/full/bjc201551a.html

Language

en