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The influence of acute moderate-to-high intensity aerobic exercise on markers of immune function and microparticles in renal transplant recipients.

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posted on 2020-03-06, 11:15 authored by Patrick J. Highton, Alice E. M. White, Daniel G. D. Nixon, Thomas J. Wilkinson, Jill Neale, Naomi Martin, Nicolette C. Bishop, Alice C. Smith
Renal transplant recipients (RTRs) and non-dialysis chronic kidney disease (ND-CKD) patients display elevated circulating microparticle (MP) counts, whilst RTRs display immunosuppression-induced infection susceptibility. The impact of aerobic exercise on circulating immune cells and microparticles is unknown in RTRs. Fifteen RTRs (age 52.8±14.5 years, estimated glomerular filtration rate [eGFR] 51.7±19.8 ml/min/1.73m2 [mean ± SD]), 16 ND-CKD patients (54. ± 6.3 years, eGFR 61.9±21.0 ml/min/1.73m2, acting as a uremic control group), and 16 HCs (52.2±16.2 years, eGFR 85.6±6.1 ml/min/1.73m2) completed 20 minutes of walking at 60-70% VO2 peak. Venous blood samples were taken pre, post, and 1h post-exercise. Leukocytes and MPs were assessed using flow cytometry. Exercise increased classical (p = 0.001) and non-classical (p = 0.002) monocyte subset proportions but decreased the intermediate subset (p < 0.001) in all groups. Exercise also decreased the percentage of platelet-derived MPs that expressed tissue factor (TF+) in all groups (p = 0.01), though no other exercise-dependent effects were observed. The exercise-induced reduction in intermediate monocyte percentage suggests an anti-inflammatory effect, though this requires further investigation. The reduction in the percentage of TF+ platelet-derived MPs suggests reduced pro-thrombotic potential, though further functional assays are required. Exercise did not cause aberrant immune cell activation, suggesting its safety from an immunological standpoint (ISRCTN38935454).

History

Citation

Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F76-F85

Author affiliation

Department of Health Science

Version

  • AM (Accepted Manuscript)

Published in

American Journal of Physiology - Renal physiology

Volume

318

Issue

1

Pagination

F76-F85

Publisher

American Physiological Society

issn

1931-857X

eissn

1522-1466

Acceptance date

2019-11-14

Copyright date

2020

Available date

2019-12-18

Publisher version

https://journals.physiology.org/doi/abs/10.1152/ajprenal.00332.2019

Spatial coverage

United States

Language

eng

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