University of Leicester
Browse
IJO_ChildrenofSCOPE_Main Text_NoHL.pdf (160.97 kB)

The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study

Download (160.97 kB)
journal contribution
posted on 2017-09-20, 14:02 authored by Veronica T. Boyle, Eric B. Thorstensen, John M. D. Thompson, Lesley M. E. McCowan, Edwin A. Mitchell, Keith M. Godfrey, Lucilla Poston, Clare R. Wall, Rinki Murphy, Wayne Cutfield, Tim Kenealy, Louise C. Kenny, Philip N. Baker
BACKGROUND: Vitamin D insufficiency (defined as <75 nmol/l) is widespread amongst pregnant women around the world and has been proposed to influence offspring outcomes in childhood and into adult life, including adiposity and allergy. Disorders including asthma and eczema are on the rise amongst children. Our aim was to investigate the relationship between maternal 25-hydroxyvitamin D status in pregnancy and offspring adiposity, asthma and eczema in childhood. SUBJECTS AND METHODS: Maternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks' gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints (SCOPE) cohort study. The offspring of 1208 mothers were followed up at age 5-6 years. Data collected included height, weight, percentage body fat (PBF, measured by bioimpedence) and history of asthma and eczema. Multivariable analysis controlled for maternal BMI, age and sex of the child and season of serum sampling. RESULTS: Complete data were available for 922 mother-child pairs. Each 10 nmol/l increase in maternal 25-hydroxyvitamin D concentration at 15 weeks' gestation was associated with a decrease in offspring PBF of 0.2% (95% CI 0.04-0.36% P=0.01) after adjustment for confounders, but was not related to child BMI z-score. Maternal mean (±s.d.) 25-hydroxyvitamin D concentration was similar in children who did and did not have asthma (71.7±26.1 vs 73.3±27.1 nmol/l P=0.5), severe asthma (68.6±28.6 vs 73.3±26.8 nmol/l P=0.2) and eczema (71.9±27.0 vs 73.2±27.0 nmol/l P=0.5). CONCLUSIONS: The finding of a relationship between maternal vitamin D status and adiposity in childhood is important, particularly because vitamin D insufficiency in pregnancy is highly prevalent. The association between maternal vitamin D supplementation in pregnancy and adiposity in the offspring merits examination in randomised controlled trials.

History

Citation

International Journal of Obesity, 2017, 41, pp. 1755–1760

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY

Version

  • AM (Accepted Manuscript)

Published in

International Journal of Obesity

Publisher

Nature Publishing Group

issn

0307-0565

eissn

1476-5497

Copyright date

2017

Available date

2018-02-04

Publisher version

http://www.nature.com/articles/ijo2017182

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    No categories selected

    Keywords

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC