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The stability of blood Eosinophils in chronic obstructive pulmonary disease
journal contributionposted on 2020-05-07, 12:03 authored by GH Long, T Southworth, U Kolsum, GC Donaldson, JA Wedzicha, CE Brightling, D Singh
Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.
This study was funded by the MRC (United Kingdom). DS is supported by the NIHR Manchester BRC.
CitationRespiratory Research, 2020, Vol. 21:15
Author affiliationInstitute for Lung Health
- VoR (Version of Record)