University of Leicester
Browse
stroke_scirep_2023.pdf (2.32 MB)

Three-dimensional simulations of embolic stroke and an equation for sizing emboli from imaging

Download (2.32 MB)
journal contribution
posted on 2023-04-14, 13:33 authored by JP Hague, J Keelan, L Beishon, D Swienton, TG Robinson, EML Chung
Stroke simulations are needed to run in-silico trials, develop hypotheses for clinical studies and to interpret ultrasound monitoring and radiological imaging. We describe proof-of-concept three-dimensional stroke simulations, carrying out in silico trials to relate lesion volume to embolus diameter and calculate probabilistic lesion overlap maps, building on our previous Monte Carlo method. Simulated emboli were released into an in silico vasculature to simulate 1000 s of strokes. Infarct volume distributions and probabilistic lesion overlap maps were determined. Computer-generated lesions were assessed by clinicians and compared with radiological images. The key result of this study is development of a three-dimensional simulation for embolic stroke and its application to an in silico clinical trial. Probabilistic lesion overlap maps showed that the lesions from small emboli are homogeneously distributed throughout the cerebral vasculature. Mid-sized emboli were preferentially found in posterior cerebral artery (PCA) and posterior region of the middle cerebral artery (MCA) territories. For large emboli, MCA, PCA and anterior cerebral artery (ACA) lesions were comparable to clinical observations, with MCA, PCA then ACA territories identified as the most to least probable regions for lesions to occur. A power law relationship between lesion volume and embolus diameter was found. In conclusion, this article showed proof-of-concept for large in silico trials of embolic stroke including 3D information, identifying that embolus diameter could be determined from infarct volume and that embolus size is critically important to the resting place of emboli. We anticipate this work will form the basis of clinical applications including intraoperative monitoring, determining stroke origins, and in silico trials for complex situations such as multiple embolisation.

Funding

EPSRC Grant No. EP/P505046/1. Dunhill Medical Trust (RTF1806\27).

History

Citation

Hague, J.P., Keelan, J., Beishon, L. et al. Three-dimensional simulations of embolic stroke and an equation for sizing emboli from imaging. Sci Rep 13, 3021 (2023). https://doi.org/10.1038/s41598-023-29974-2

Author affiliation

Department of Cardiovascular Sciences

Version

  • VoR (Version of Record)

Published in

Scientific Reports

Volume

13

Issue

1

Pagination

3021

Publisher

Springer Science and Business Media LLC

issn

2045-2322

eissn

2045-2322

Acceptance date

2023-02-14

Copyright date

2023

Available date

2023-04-14

Spatial coverage

England

Language

eng

Usage metrics

    University of Leicester Publications

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC