Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T..pdf (1.62 MB)
Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
journal contributionposted on 2016-12-14, 16:46 authored by J. S. Burns, L. Lemoine, N. R. Lemoine, E. D. Williams, D. Wynford-Thomas
A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.
We are grateful to the Medical Research Council and to the Cancer Research Campaign of Great Britain for grant support.
CitationBritish Journal of Cancer (1989) 59, 755–760.
Author affiliation/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine
- VoR (Version of Record)