posted on 2016-12-14, 16:46authored byJ. S. Burns, L. Lemoine, N. R. Lemoine, E. D. Williams, D. Wynford-Thomas
A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.
Funding
We are grateful to the Medical Research Council and to the Cancer
Research Campaign of Great Britain for grant support.
History
Citation
British Journal of Cancer (1989) 59, 755–760.
Author affiliation
/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine