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Trajectories of behavioural problems from childhood to early adulthood following extremely preterm birth: a prospective cohort study

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posted on 2019-07-03, 11:10 authored by Louise Linsell, Samantha Johnson, Dieter Wolke, Joan Morris, Jennifer J. Kurinczuk, Neil Marlow
To investigate trajectories of behavior, attention, social and emotional problems to early adulthood in extremely preterm survivors compared to a term-born comparison group. Longitudinal analysis of a prospective, population-based cohort of 315 surviving infants born < 26 completed weeks of gestation recruited at birth in 1995, from the UK/Republic of Ireland, and a term-born comparison group recruited at age 6. The parent-report Strengths and Difficulties Questionnaire was completed at age 6, 11, 16 and 19 years. The Total Behavioral Difficulties Score was 4.81 points higher in extremely preterm individuals compared to their term-born peers over the period (95% CI 3.76–5.87, p < 0.001) and trajectories were stable in both groups. The impact of difficulties on home life, friendships, school or work and/or leisure activities was greater in the EPT group (RR 4.28, 95% CI 2.89–6.35, p < 0.001), and hyperactivity/inattention and peer problems accounted for the largest differences. A clinically significant behavioral screen at age 2.5 was associated with a higher Total Behavioral Difficulties Score from 6 years onwards in extremely preterm participants (Mean difference 6.90, 95% CI 5.01–8.70, p < 0.0.01), as was moderate/severe cognitive impairment at last assessment (Mean difference: 4.27, 95% CI 2.76–5.77, p < 0.001). Attention, social and emotional problems in extremely preterm individuals persist into early adulthood with significant impact on daily life. A positive behavioral screen in infancy and moderate/severe cognitive impairment are associated with early adult outcomes.

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Citation

European Child and Adolescent Psychiatry, 2019, 28 (4), pp. 531-542

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences

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  • VoR (Version of Record)

Published in

European Child and Adolescent Psychiatry

Publisher

Springer Verlag

issn

1018-8827

eissn

1435-165X

Acceptance date

2018-08-28

Copyright date

2018

Available date

2019-07-03

Publisher version

https://link.springer.com/article/10.1007/s00787-018-1219-8

Language

en

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