University of Leicester
journal.pone.0194986.pdf (2.69 MB)

Trends in congenital anomalies in Europe from 1980 to 2012

Download (2.69 MB)
journal contribution
posted on 2018-05-03, 12:52 authored by J. K. Morris, A. L. Springett, R. Greenlees, M. Loane, M.-C. Addor, L. Arriola, I. Barisic, J. E. H. Bergman, M. Csaky-Szunyogh, C. Dias, Elizabeth S. Draper, E. Garne, M. Gatt, B. Khoshnood, K. Klungsoyr, C. Lynch, R. McDonnell, V. Nelen, A. J. Neville, M. O'Mahony, A. Pierini, A. Queisser-Luft, H. Randrianaivo, J. Rankin, A. Rissmann, J. Kurinczuk, D. Tucker, C. Verellen-Dumoulin, D. Wellesley, H. Dolk
BACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens. METHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. RESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing. CONCLUSIONS: The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5% (3.5% to 9.4%)] and decreased prevalence of limb reduction defects [-2.8% (-4.2% to -1.5%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.



PLoS One, 2018, 13 (4), e0194986

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences


  • VoR (Version of Record)

Published in

PLoS One


Public Library of Science



Acceptance date


Copyright date


Available date


Publisher version



Usage metrics

    University of Leicester Publications