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Uncovering physiological mechanisms for health disparities in type 2 diabetes

journal contribution
posted on 2015-11-02, 12:52 authored by A. E. Staiano, Deirdre M. Harrington, N. M. Johannsen, R. L. Newton, M. A. Sarzynski, D. L. Swift, P. T. Katzmarzyk
Type 2 diabetes (T2D) prevalence in the United States is significantly higher in African Americans vs Whites. Yet, the physiological mechanisms contributing to this health disparity have been poorly described. To design effective strategies to reduce this disparity, there is a need to determine whether racial differences in diabetes prevalence are attributable to modifiable or non-modifiable factors. This review synthesizes and critically evaluates the potential physiological and genetic mechanisms that may contribute to the higher susceptibility of African Americans to T2D. These mechanisms include: 1) obesity and fat distribution; 2) metabolic flexibility; 3) muscle physiology; 4) energy expenditure and fitness; and 5) genetics. We focus on the clinical significance of findings and limitations of the recent literature.

History

Citation

Ethnicity and Disease , 2015, 25 (1), pp. 31-37

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine

Version

  • AM (Accepted Manuscript)

Published in

Ethnicity and Disease

Publisher

International Society on Hypertension in Blacks

issn

1049-510X

Copyright date

2015

Publisher version

http://www.ishib.org/wordpress/?page_id=2705

Notes

The file associated with this record is under a permanent embargo while permission to archive is sought from the publisher. The full text may become available through the publisher links above.

Language

en

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