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United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol.

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posted on 2022-08-26, 10:47 authored by Lucy Teece, Laura J. Gray, Carl Melbourne, Chris Orton, David V. Ford, Christopher A. Martin, David McAllister, Kamlesh Khunti, Martin Tobin, Catherine John, Keith R Abrams, Manish Pareek, UK-REACH Study Collaborative Group

Introduction: COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in people working in healthcare settings is insufficient to inform plans to address health inequalities.

Methods and analysis: This study combines anonymised human resource databases with professional registration and National Health Service data sets to assess associations between ethnicity and COVID-19 diagnosis, hospitalisation and death in healthcare workers in the UK. Adverse COVID-19 outcomes will be assessed between 1 February 2020 (date following first confirmed COVID-19 case in UK) and study end date (31 January 2021), allowing 1-year of follow-up. Planned analyses include multivariable Poisson, logistic and flexible parametric time-to-event regression within each country, adjusting for core predictors, followed by meta-analysis of country-specific results to produce combined effect estimates for the UK. Mediation analysis methods will be explored to examine the direct, indirect and mediated interactive effects between ethnicity, occupational group and COVID-19 outcomes.

Ethics and dissemination: Ethical approval for the UK-REACH programme has been obtained via the expedited HRA COVID-19 processes (REC ref: 20/HRA/4718, IRAS ID: 288316). Research information will be anonymised via the Secure Anonymised Information Linkage Databank before release to researchers. Study results will be submitted for publication in an open access peer-reviewed journal and made available on our dedicated website (https://uk-reach.org/).

Trial registration number: ISRCTN11811602.

History

Citation

BMJ Open 2021;11:e046392

Author affiliation

Department of Respiratory Sciences

Version

  • VoR (Version of Record)

Published in

BMJ open

Volume

11

Issue

6

Publisher

BMJ Publishing Group

issn

2044-6055

eissn

2044-6055

Acceptance date

2021-06-04

Copyright date

2021

Available date

2022-08-26

Notes

GOLD - doi not working at the time of the OA deposit check (July 2021) but LTs considered the article to be GOLD OA. Unpaywall could not comment on the publication as the doi was not working.

Spatial coverage

England

Language

eng

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