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Using predictions from a joint model for longitudinal and survival data to inform the optimal time of intervention in an abdominal aortic aneurysm screening programme.pdf (273.23 kB)

Using predictions from a joint model for longitudinal and survival data to inform the optimal time of intervention in an abdominal aortic aneurysm screening programme.

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journal contribution
posted on 2018-04-26, 15:25 authored by Michael J. Sweeting
Joint models of longitudinal and survival data can be used to predict the risk of a future event occurring based on the evolution of an endogenous biomarker measured repeatedly over time. This has led naturally to the use of dynamic predictions that update each time a new longitudinal measurement is provided. In this paper, we show how such predictions can be utilised within a fuller decision modelling framework, in particular to allow planning of future interventions for patients under a 'watchful waiting' care pathway. Through the objective of maximising expected life-years, the predicted risks associated with not intervening (e.g. the occurrence of severe sequelae) are balanced against risks associated with the intervention (e.g. operative risks). Our example involves patients under surveillance in an abdominal aortic aneurysm screening programme where a joint longitudinal and survival model is used to associate longitudinal measurements of aortic diameter with the risk of aneurysm rupture. We illustrate how the decision to intervene, which is currently based on a diameter measurement greater than a certain threshold, could be made more personalised and dynamic through the application of a decision modelling approach.

History

Citation

Biometrical Journal, 2017, 59 (6), pp. 1247-1260

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences

Version

  • VoR (Version of Record)

Published in

Biometrical Journal

Publisher

Wiley-VCH Verlag

issn

0323-3847

eissn

1521-4036

Acceptance date

2017-02-27

Copyright date

2017

Available date

2018-04-26

Publisher version

https://onlinelibrary.wiley.com/doi/abs/10.1002/bimj.201600222

Language

en

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