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Value of P‐wave Parameters in Predicting Outcomes of Repeat Catheter Ablation for Paroxysmal Atrial Fibrillation

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posted on 2025-09-18, 11:17 authored by Ibrahim Antoun, Xin LiXin Li, Zakkariya Vali, Ivelin Koev, Riyaz Somani, Ghulam NgGhulam Ng
<p dir="ltr">BackgroundPulmonary vein isolation (PVI) has been established as an effective management option for symptomatic paroxysmal atrial fibrillation (PAF). We aimed to explore the role of P‐wave parameters in a 12‐lead electrocardiogram (ECG) in predicting the success of repeat PAF ablation.MethodsWe enrolled consecutive patients who underwent a second AF ablation procedure for PAF in a UK tertiary center after an index ablation conducted between 2018 and 2019 and a repeat ablation up to 2021. A digital 12‐lead ECG was recorded with a 1–50‐Hz bandpass filter applied. P‐wave duration (PWD), P‐wave voltage (PWV), P‐wave dispersion (PWDisp), and P‐wave terminal force in V1 (PTFV1) were measured before and after the procedure. Changes were correlated with the 12‐month clinical outcome. Procedural success was freedom from ECG‐documented AF up to 12 months following ablation.ResultsStudy criteria were satisfied by 72 patients, of which 43 (60%) had successful repeat PVI at 12 months. The mean age is 65, and 47 (65%) were males. The demographics were comparable between both study arms. PWD decreased after successful repeat ablations (136.7 to 124.6 ms, p = 0.01) and failed repeat ablations (135.4 to 125.3 ms, p = 0.009) without a significant change between both arms. PMV and PWDisp did not change significantly after both study arms. PTFV1 significantly decreased after successful repeat ablations (‐3.1 to ‐4.4 mm.s, p = 0.005) without a significant change after failed ablations (‐2.9 to ‐2.7 mm.s, p = 0.42). Changes were statistically significant between both arms (p = 0.004).ConclusionPTFV1 reduction following the second AF ablation was correlated with successful repeat AF ablation at 12 months.</p>

Funding

Neurocardiac interaction in malignant ventricular arrhythmias and sudden cardiac death

British Heart Foundation

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Development of a successful novel technology for sudden cardiac death risk stratification for clinical use - LifeMap

Medical Research Council

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History

Author affiliation

College of Life Sciences College of Science & Engineering Medical Sciences Engineering

Version

  • VoR (Version of Record)

Published in

Pacing and Clinical Electrophysiology

Volume

48

Issue

1

Pagination

36 - 41

Publisher

Wiley

issn

0147-8389

eissn

1540-8159

Copyright date

2025

Available date

2025-09-18

Spatial coverage

United States

Language

en

Deposited by

Dr Ibrahim Antoun

Deposit date

2025-08-29

Data Access Statement

The authors will make the raw data supporting this article's conclusions available upon reasonable request.