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Visible-light-mediated aerobic Ritter-type C-H amination of diarylmethanes using DDQ/tert-butyl nitrite.

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posted on 2023-07-14, 10:26 authored by Tianci Li, Jiangyu Yang, Xin Yin, Jinhua Shi, Qun Cao, Miaomiao Hu, Xiaowen Xu, Meichao Li, Zhenlu Shen
A metal-free photocatalytic Ritter-type C-H amination of unactivated sp3 carbons using molecular oxygen as a terminal oxidant has been developed. By employing a co-catalytic system of 3-dichloro-4,5-dicyano-1,4-benzoquinone (DDQ) and tert-butyl nitrite (TBN), this novel strategy provides a low cost, sustainable and scalable way to synthesise a broad range of secondary amides in moderate to excellent yields under mild conditions.

Funding

National Natural Science Foundation of China (22178321, 21773211 and 21776260) and the Key Research and Development Project of Zhejiang Province (no. 2021C01079).

History

Author affiliation

School of Chemistry, University of Leicester

Version

  • VoR (Version of Record)

Published in

Organic & biomolecular chemistry

Volume

20

Issue

44

Pagination

8756 - 8760

Publisher

Royal Society of Chemistry

issn

1477-0520

eissn

1477-0539

Copyright date

2022

Available date

2023-07-14

Spatial coverage

England

Language

eng

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