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What does SARS-CoV-2 tell us about the aetiology of environmental triggers for diabetes in children and young people?

journal contribution
posted on 2023-10-10, 08:45 authored by C Ponmani, MD Lyttle, M Barrett, T Hulse, RG Nijman, D Roland, the DIMPLES study group

Type 1 diabetes mellitus (T1DM) is caused by the autoimmune destruction of β cells in the pancreatic islets and accounts for over 90% of childhood diabetes. A significant increase in new-onset childhood T1DM has been reported in the COVID-19 pandemic,1-4 but the link with SARS-CoV-2 remains an enigma. This quandary is not unique to SARS-CoV-2. Despite over 100 years of investigation, the search for contributing environmental triggers, and the extent to which they play a role in the aetiology and progression of new-onset diabetes remains a challenge. 

History

Author affiliation

Department of Health Sciences, University of Leicester

Version

  • AM (Accepted Manuscript)

Published in

Acta Paediatrica, International Journal of Paediatrics

Publisher

Wiley

issn

0803-5253

eissn

1651-2227

Copyright date

2023

Available date

2024-09-11

Spatial coverage

Norway

Language

eng

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