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When Laughter Knocks You Out: A Case of Laughing‐Induced Syncope and a Review of the Literature

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posted on 2025-11-03, 11:05 authored by Stephanie Abutu, Mohammad El‐Din, Prashanth Raju, Ibrahim AntounIbrahim Antoun
<p dir="ltr">Significant implications, particularly in high‐risk settings such as driving. This case highlights the diagnostic challenges in identifying this condition, which necessitate a comprehensive evaluation to rule out structural or electrical cardiac abnormalities and confirm the diagnosis through careful monitoring. The proposed pathophysiology involves exaggerated vagal responses or inappropriate sympathetic withdrawal, although the exact mechanisms remain unclear. Management hinges on a tailored, trigger‐focused approach, emphasizing patient education and behavioral modifications to prevent a recurrence. Increased awareness of laughter‐induced syncope is vital for timely diagnosis, effective management, and the prevention of serious adverse outcomes.</p>

History

Author affiliation

University of Leicester College of Life Sciences Medical Sciences

Version

  • VoR (Version of Record)

Published in

Clinical Case Reports

Volume

13

Issue

10

Pagination

e71297

Publisher

Wiley

issn

2050-0904

eissn

2050-0904

Copyright date

2025

Available date

2025-11-03

Language

en

Deposited by

Dr Ibrahim Antoun

Deposit date

2025-10-18

Data Access Statement

Data relating to this study is available upon reasonable request from the corresponding author.

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