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INTERACT2 Treatment withdrawal following ICH FINAL ANONYMISED Age Ageing july2016 CLEAN.pdf (251.81 kB)
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Withdrawal of active treatment after intracerebral haemorrhage in the INTERACT2 study

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posted on 2017-11-23, 10:33 authored by Paula Muñoz Venturelli, Xia Wang, Darin B. Zahuranec, Pablo M. Lavados, Christian Stapf, Richard Lindley, Candice Delcourt, John Chalmers, Craig S. Anderson, Thompson G. Robinson, INTERACT2 Investigators
Background: in the second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2), a minority of patients received withdrawal of active treatment (WAT). We wished to determine the characteristics of these patients, and the relation of this decision-making to subsequent management and final outcome. Methods: the INTERACT2 cohort of acute intracerebral haemorrhage (ICH) patients had a decision of WAT within 7 days after hospital admission recorded. Multivariable logistic regression was used to identify the determinants of WAT and poor outcome at 90 days, defined by modified Rankin scale (mRS) scores 3-6. Results: of 2,779 participants with available data, WAT occurred in 121 (4%) and this was significantly associated with increasing age, greater neurological severity, larger haematoma volume, intraventricular extension and randomisation to intensive BP lowering. Compared to other patients, those with WAT had greater mortality (81/121 [67%] versus 205/2624 [8%]; P < 0.001) and survivors were more likely to be severely disabled (mRS score 4-5, 19/39 [49%] versus 695/2419 [29%]; P = 0.006). Conclusions: WAT was undertaken in patients with recognised predictors of poor prognosis, who subsequently were more likely to die or be left with severe disability. Improved understanding of specific factors determining WAT in ICH patients might improve care delivery and outcomes. Clinical Trial Registration: the INTERACT2 study is registered with (NCT00716079).



Age and Ageing, 2017, 46 (2), pp. 329-332

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/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences


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Age and Ageing


Oxford University Press for British Geriatrics Society





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