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Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits.pdf (1.01 MB)

Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits

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posted on 2018-03-12, 12:00 authored by Laurence J. Howe, Mesut A. Erzurumluoglu, George Davey Smith, Santiago Rodriguez, Evie Stergiakouli
Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect.

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Citation

Scientific Reports, 2017, 7, Article number: 11655

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

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  • VoR (Version of Record)

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Scientific Reports

Publisher

Nature Publishing Group

eissn

2045-2322

Acceptance date

2017-08-15

Copyright date

2017

Available date

2018-03-12

Publisher version

http://www.nature.com/articles/s41598-017-10871-4

Language

en

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