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ß-defensins and Crohn's disease: confusion from counting copies

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journal contribution
posted on 2010-06-14, 10:15 authored by Edward J. Hollox
Recent research has suggested that a family of antimicrobial and inflammatory molecules, called β-defensins, are involved in the etiology of Crohn's disease. In this issue, Bentley and colleagues provide data that disagree with previous studies. They show that the β-defensins that are copy number polymorphic have, on average, higher genomic copy number in patients when compared with healthy controls. This editorial places these new data in the context of previous research on the genetics of β-defensin copy number polymorphism and association with Crohn's disease. It also suggests a path allowing this research area to move forward with confidence.

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Citation

American Journal Gastroenterology, 2009, 105(2), pp.360–362

Published in

American Journal Gastroenterology

Publisher

Nature Publishing Group

issn

0002-9270;1572-0241

Copyright date

2009

Available date

2010-06-14

Publisher version

http://www.nature.com/ajg/journal/v105/n2/full/ajg2009573a.html

Language

en

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