Atrial Electrogram Complexity as a Clinical Instrument for Measuring Temporal Fractionation Variability during Atrial Fibrillation

Regions of the atria with complex fractionated atrial electrograms (CFEs) have been suggested to represent remodelled atrial substrate, and hence important sites for ablation in patients with persistent AF. However, temporal behaviour of complex fractionated atrial electrograms (CFEs) remains ill defined. In this study we introduce Negentropy (NegEn) as a measurement of electrogram (EGM) complexity and compare its use in measuring CFEs temporal behaviour with current algorithms based on time domain. [Taken from the Introduction]