PTLD case report manuscript.docx (32.93 kB)
Native lung pneumonectomy for post-transplantation lymphoproliferative disorder refractory to rituximab following contralateral lung transplantation
journal contribution
posted on 2020-04-08, 13:24 authored by Marius Roman, Jasvir Parmar, Martin Goddard, Piergiorgio SolliPost-transplantation lymphoproliferative disorder (PTLD) is a life-threatening complication following lung transplantation. We report a PTLD case of high-grade, B-cell lymphoma following contralateral single-lung transplantation. The disease involved the liver, right kidney and right native lung. While the PTLD affecting the abdominal organs regressed with rituximab chemotherapy, the native lung disease progressed and was treated surgically (right pneumonectomy). Some aspects are unique in this case: (i) different response to medical treatment between lung and abdominal organs; (ii) absolute absence of involvement of the native lung and (iii) surgical treatment with a pneumonectomy, still very rarely described in the literature. We hypothesized that a different morphotype of the disease involved the abdominal organs or the penetrance of rituximab, and chemotherapy could have been impaired by the presence of pulmonary fibrosis.
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Citation
Marius Roman, Jasvir Parmar, Martin Goddard, Piergiorgio Solli, Native lung pneumonectomy for post-transplantation lymphoproliferative disorder refractory to rituximab following contralateral lung transplantation, Interactive CardioVascular and Thoracic Surgery, Volume 23, Issue 5, November 2016, Pages 841–843, https://doi.org/10.1093/icvts/ivw235Version
- AM (Accepted Manuscript)
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INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERYVolume
23Issue
5Pagination
841 - 843 (3)Publisher
OXFORD UNIV PRESSissn
1569-9293eissn
1569-9285Acceptance date
2016-06-15Copyright date
2016Available date
2016-07-15Publisher DOI
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https://academic.oup.com/icvts/article/23/5/841/2399441Language
EnglishUsage metrics
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