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Physiological state gates acquisition and expression of mesolimbic reward prediction signals

journal contribution
posted on 2016-02-04, 12:12 authored by J. J. Cone, S. M. Fortin, J. McHenry, G. D. Stuber, James E. McCutcheon, M. F. Roitman
Phasic dopamine signaling participates in associative learning by reinforcing associations between outcomes (unconditioned stimulus; US) and their predictors (conditioned stimulus; CS). However, prior work has always engendered these associations with innately rewarding stimuli. Thus, whether dopamine neurons can acquire prediction signals in the absence of appetitive experience and update them when the value of the outcome changes remains unknown. Here, we used sodium depletion to reversibly manipulate the appetitive value of a hypertonic sodium solution while measuring phasic dopamine signaling in rat nucleus accumbens. Dopamine responses to the NaCl US following sodium depletion updated independent of prior experience. In contrast, prediction signals were only acquired through extensive experience with a US that had positive affective value. Once learned, dopamine prediction signals were flexibly expressed in a state-dependent manner. Our results reveal striking differences with respect to how physiological state shapes dopamine signals evoked by outcomes and their predictors.

History

Citation

Proceedings of the National Academy of Sciences of USA, 2016, 113(7), pp. 1943-1948

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour

Version

  • AM (Accepted Manuscript)

Published in

Proceedings of the National Academy of Sciences of USA

Publisher

National Academy of Sciences

issn

1091-6490

Acceptance date

2016-01-08

Copyright date

2016

Available date

2016-03-09

Publisher version

http://www.pnas.org/content/113/7/1943.short

Notes

The file associated with this record is under a permanent embargo while publication is In Press in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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