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Visualisation of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness
journal contribution
posted on 2023-01-20, 11:33 authored by Wadah Ibrahim, Michael J Wilde, Rebecca Cordell, Matthew Richardson, Dahlia Salman, Robert Free, Bo Zhao, Amisha Singapuri, Beverley Hargadon, Erol Gaillard, Toru Suzuki, Leong Ng, Tim Coats, Paul Thomas, Paul S Monks, Chris Brightling, Neil Greening, Salman SiddiquiBreath analysis can be a useful noninvasive way to detect disease. Here, Ibrahim et al. studied the volatile organic compound (VOC) signatures associated with acute cardiorespiratory diseases in patients presenting breathlessness. Using two-dimensional gas chromatography and mass spectrometry, the authors found clusters of VOCs associated with acute heart failure, asthma, chronic obstructive pulmonary disease, and pneumonia. These breath biomarkers correlated with blood-based biomarkers. An acute disease VOC score based on a 101-biomarker panel was associated with 2-year all-cause mortality. This study demonstrates how breathomics can help diagnose disease and further our understanding of metabolic subgroups.
Funding
Attenuating the effects of hospital-associated disability in exacerbations of Chronic Obstructive Pulmonary Disease using an anabolic intervention: a randomised controlled feasibility study
NIHR Academy
Find out more...Research funding was provided by the MRC and EPSRC Stratified Medicine Grant for Molecular Pathology Nodes (Grant No. MR/N005880/1). The research was supported by the National Institute for Health Research (NIHR )Leicester Biomedical Research Centre and NIHR, Leicester Clinical Research Facility, the Leicester Wellcome Trust ISSF (Award No. 204801/Z/16/Z), and the Midlands Asthma and Allergy Research Association(MAARA) to whom we are extremely grateful. N.J.G. is funded by a NIHR post doctoral fellowship (PDF 2017 10 052)
History
Author affiliation
Department of Respiratory Sciences, University of LeicesterVersion
- AM (Accepted Manuscript)
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Science Translational MedicineVolume
14Issue
671Pagination
eabl5849Publisher
American Association for the Advancement of Scienceissn
1946-6234eissn
1946-6242Copyright date
2022Available date
2023-01-20Publisher DOI
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United StatesLanguage
engPublisher version
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